Intravenous Lipid Emulsion (ILE) Therapy for Severe Felodipine Toxicity | Zendy

Lee RC Barnicott | Zendy; Nick T Tarmey | Zendy; Gordon Craig | Zendy; Simon HL Thomas | Zendy

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Intravenous Lipid Emulsion (ILE) Therapy for Severe Felodipine Toxicity

Author(s) -

Lee RC Barnicott,

Nick T Tarmey,

Gordon Craig,

Simon HL Thomas

Publication year - 2013

Publication title -

journal of the intensive care society

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.551

H-Index - 14

eISSN - 2057-360X

pISSN - 1751-1437

DOI - 10.1177/175114371301400415

Subject(s) - felodipine , medicine , lipid emulsion , circumstantial evidence , refractory (planetary science) , toxicity , emulsion , pharmacology , intensive care medicine , chemistry , parenteral nutrition , biochemistry , physics , astrobiology , political science , blood pressure , law

Intravenous lipid emulsion (ILE) is increasingly used for the treatment of poisoning caused by lipid-soluble drugs. We report a case of reversal of cardiovascular collapse after the use of ILE in a patient with a mixed overdose, mainly of the calcium channel blocker felodipine. Conclusions that can be drawn from a single case are limited, but this report provides circumstantial evidence of benefit of ILE for felodipine poisoning. The use of ILE appears justified in cases refractory to conventional therapy.

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