A Randomised Trial on the Treatment of Refractory Status Epilepticus | Zendy

Emma M. Jenkinson | Zendy; Laura Tulloch | Zendy; William Tunnicliffe | Zendy

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A Randomised Trial on the Treatment of Refractory Status Epilepticus

Author(s) -

Emma M. Jenkinson,

Laura Tulloch,

William Tunnicliffe

Publication year - 2011

Publication title -

journal of the intensive care society

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.551

H-Index - 14

eISSN - 2057-360X

pISSN - 1751-1437

DOI - 10.1177/175114371101200316

Subject(s) - status epilepticus , refractory (planetary science) , medicine , mechanical ventilation , randomized controlled trial , propofol , clinical trial , anesthesia , intensive care medicine , epilepsy , psychiatry , physics , astrobiology

This study failed to show a significant difference in outcome between those receiving propofol versus barbiturates in the treatment of refractory status epilepticus, except in duration of mechanical ventilation. However, due to a failure to recruit sufficient numbers of patients, the trial was significantly underpowered and we recommend caution when drawing any conclusions from the data. Level of evidence: 1 − (RCT with a high risk of bias)

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