Survival following Profound Lactic Acidosis and Cardiac Arrest: Does Metformin Really Induce Lactic Acidosis? | Zendy

Craig Spencer | Zendy; Luka Randic | Zendy; John M. Butler | Zendy

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Survival following Profound Lactic Acidosis and Cardiac Arrest: Does Metformin Really Induce Lactic Acidosis?

Author(s) -

Craig Spencer,

Luka Randic,

John M. Butler

Publication year - 2009

Publication title -

journal of the intensive care society

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.551

H-Index - 14

eISSN - 2057-360X

pISSN - 1751-1437

DOI - 10.1177/175114370901000210

Subject(s) - lactic acidosis , metformin , medicine , acidosis , shock (circulatory) , metabolic acidosis , sepsis , septic shock , hyperlactatemia , etiology , cardiology , intensive care medicine , insulin

We report the case of a 63-year-old man who suffered a witnessed pulseless electrical activity cardiac arrest on presentation to the emergency department. Despite a profound post-arrest acidosis (pH 6.48) he went on to make an unexpectedly good recovery. He was treated for metformin-associated lactic acidosis (MALA) and septic shock, although the origin of the sepsis was never confirmed. We discuss the growing evidence against the existence of MALA as a lone diagnosis and the aetiology of post-cardiac arrest metabolic acidosis.

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