Open AccessShift models for dose-finding in partially ordered groups
Author(s) -
Bethany J. Horton,
Nolan A. Wages,
Mark R. Conaway
Publication year - 2018
Publication title -
clinical trials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.559
H-Index - 63
eISSN - 1740-7753
pISSN - 1740-7745
DOI - 10.1177/1740774518801599
Subject(s) - maximum tolerated dose , selection (genetic algorithm) , medicine , clinical trial , group selection , order (exchange) , computer science , machine learning , finance , economics
Limited options are available for dose-finding clinical trials requiring group-specific dose selection. While conducting parallel trials for groups is an accessible approach to group-specific dose selection, this approach allows for maximum tolerated dose selection that does not align with clinically meaningful group order information.
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