Molecular Imaging of Hydrolytic Enzymes Using PET and SPECT | Zendy

Brian P. Rempel | Zendy; Eric W. Price | Zendy; Christopher P. Phenix | Zendy

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Molecular Imaging of Hydrolytic Enzymes Using PET and SPECT

Author(s) -

Brian P. Rempel,

Eric W. Price,

Christopher P. Phenix

Publication year - 2017

Publication title -

molecular imaging

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.815

H-Index - 60

eISSN - 1536-0121

pISSN - 1535-3508

DOI - 10.1177/1536012117717852

Subject(s) - positron emission tomography , enzyme , hydrolysis , molecular imaging , chemistry , emission computed tomography , pet imaging , single photon emission computed tomography , biochemistry , nuclear medicine , medicine , biology , in vivo , microbiology and biotechnology

Hydrolytic enzymes are a large class of biological catalysts that play a vital role in a plethora of critical biochemical processes required to maintain human health. However, the expression and/or activity of these important enzymes can change in many different diseases and therefore represent exciting targets for the development of positron emission tomography (PET) and single-photon emission computed tomography (SPECT) radiotracers. This review focuses on recently reported radiolabeled substrates, reversible inhibitors, and irreversible inhibitors investigated as PET and SPECT tracers for imaging hydrolytic enzymes. By learning from the most successful examples of tracer development for hydrolytic enzymes, it appears that an early focus on careful enzyme kinetics and cell-based studies are key factors for identifying potentially useful new molecular imaging agents.

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