F-Actin Reorganization and Inactivation of Rho Signaling Pathway Involved in the Inhibitory Effect of Coptidis Rhizoma on Hepatoma Cell Migration | Zendy

Ning Wang | Zendy; Yibin Feng | Zendy; Echo Ping Woi Lau | Zendy; ChiMan Tsang | Zendy; Ching C. Lau | Zendy; Chiman Kwan | Zendy; Yao Tong | Zendy; Tadashi Nagamatsu | Zendy; Weiwei Su | Zendy; SaiWah Tsao | Zendy

Open Access

F-Actin Reorganization and Inactivation of Rho Signaling Pathway Involved in the Inhibitory Effect of Coptidis Rhizoma on Hepatoma Cell Migration

Author(s) -

Ning Wang,

Yibin Feng,

Echo Ping Woi Lau,

ChiMan Tsang,

Ching C. Lau,

Chiman Kwan,

Yao Tong,

Tadashi Nagamatsu,

Weiwei Su,

SaiWah Tsao

Publication year - 2010

Publication title -

integrative cancer therapies

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.73

H-Index - 60

eISSN - 1552-695X

pISSN - 1534-7354

DOI - 10.1177/1534735410379121

Subject(s) - chemistry , berberine , matrix metalloproteinase , actin cytoskeleton , cell , cell migration , microbiology and biotechnology , cancer research , cytoskeleton , biochemistry , medicine , biology

Hepatocellular carcinoma (HCC) is one of the most malignant human tumors and one of the risk factors is its highly metastatic property. Coptidis Rhizoma aqueous extract (CRAE) is able to suppress the migration and invasion of HCC cells, MHCC97-L, and F-actin reorganization and Rho signaling inhibition is involved.

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