MicroRNA-96 Regulates Apoptosis by Targeting PDCD4 in Human Glioma Cells | Zendy

Qingqing Ma | Zendy; Jian-ting Huang | Zendy; Yun-gang Xiong | Zendy; Xiaoyan Yang | Zendy; Ran Han | Zendy; Wang-wen Zhu | Zendy

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MicroRNA-96 Regulates Apoptosis by Targeting PDCD4 in Human Glioma Cells

Author(s) -

Qingqing Ma,

Jian-ting Huang,

Yun-gang Xiong,

Xiaoyan Yang,

Ran Han,

Wang-wen Zhu

Publication year - 2016

Publication title -

technology in cancer research and treatment

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.754

H-Index - 63

eISSN - 1533-0346

pISSN - 1533-0338

DOI - 10.1177/1533034616629260

Subject(s) - microrna , glioma , apoptosis , cancer research , transfection , downregulation and upregulation , gene knockdown , biology , metastasis , in vivo , suppressor , u87 , cancer , cell culture , gene , genetics

Glioblastoma multiforme, the most common and aggressive form of primary brain tumor, presents a dismal prognosis. MicroRNAs play a critical role in the initiation, progression, and metastasis of cancer; however, the potential biological role of miRNAs in glioblastoma multiforme remains largely unknown. In our study, we found that microRNA-96 is upregulated in glioma tissues than in normal human brains. Transfection of microRNA-96 mimics into glioma cells significantly decreases apoptosis by suppressing PDCD4, a well-known tumor suppressor that is involved in apoptosis. In contrast, knockdown of microRNA-96 enhanced apoptosis. In vivo, microRNA-96 overexpression inhibits the apoptosis and increases tumor growth. These data suggest that microRNA-96 is a potential molecular target for glioma treatment.

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