Open AccessExpression and Clinical Significance of MMP-28 in Bladder Cancer
Author(s) -
Heng Wang,
Jingzhu Wu,
Xin-Peng Chen,
Qi Zhang,
Haibin Wei,
Hui-Ju Wang,
Xue Yang,
Dahong Zhang
Publication year - 2020
Publication title -
technology in cancer research and treatment
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.754
H-Index - 63
eISSN - 1533-0346
pISSN - 1533-0338
DOI - 10.1177/1533033820974017
Subject(s) - medicine , bladder cancer , immunohistochemistry , pathology , lymphovascular invasion , urinary bladder , carcinoma , downregulation and upregulation , metastasis , clinical significance , infiltration (hvac) , urothelium , cancer , matrix metalloproteinase , lymph node , tumor progression , oncology , urology , biology , biochemistry , physics , gene , thermodynamics
Aims: The aim of this study to determine the expression of MMP-28 in bladder urothelial carcinoma and to analyze the correlation between MMP-28 and the clinicopathological characteristics of human bladder carcinoma, and its relationship with patient prognosis.Methods: A total of 491 surgically resected bladder cancer samples and 80 normal tissue adjacent to the tumor were stained by immunohistochemistry. The expression of MMP-28 in these samples was quantitated, and the value of MMP-28 as a marker of bladder cancer and prognosis was assessed.Results: The expression of MMP-28 in urinary bladder carcinoma was higher than in normal bladder mucosa. The high level of MMP-28 was significantly correlated with tumor histology grade, lymphatic metastasis, lymph node infiltration, and distant metastasis (P < 0.05). The upregulation of MMP-28 was also closely related to the risk of cancer progression and the survival of patients. Further analysis documented that high expression of MMP-28 was associated with decreased overall survival in bladder cancer patients.Conclusions: The abnormal expression of MMP-28 may be related to the initiation and development of urothelial carcinoma. The upregulation of MMP-28 can be used as one of the effective indicators to diagnose bladder cancer and predict tumor progression.