Open AccessRed Cell Indices and Functions Differentiating Patients with the β-Thalassaemia Trait from those with Iron Deficiency Anaemia
Author(s) -
Vahap Okan,
Ahmet Çiğiloğlu,
Sami Çifçi,
Mehmet Yılmaz,
Mustafa Pehlıvan
Publication year - 2009
Publication title -
journal of international medical research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.421
H-Index - 57
eISSN - 1473-2300
pISSN - 0300-0605
DOI - 10.1177/147323000903700103
Subject(s) - medicine , red blood cell distribution width , youden's j statistic , gastroenterology , iron deficiency , anemia , predictive value
This study examined the diagnostic accuracy of nine indices to discriminate between patients with mild-to-moderate (haemoglobin 8.5 − 11 g/dl) or moderate-to-severe (haemoglobin G&K > E&F > RBC = RDWI > MI > S > R > RDW to differentiate between β-TT and mild-to-moderate IDA; and S&L > G&K > E&F = RDWI > RBC > R > MI > S > RDW to differentiate between β-TT or moderate-to-severe IDA. For both groups, S&L and G&K offered the best discrimination and RDW the worst. S&L showed the highest Youden index for β-TT and IDA discrimination, but sensitivity and specificity were not 100%. In both mild and severe IDA, the S&L index may be used to differentiate cases of β-TT from IDA cases, but large clinical trials are needed to explore this further.