Open AccessOxidant/antioxidant Parameters and their Relationship with Chemotherapy in Hodgkin's Lymphoma
Author(s) -
Emin Kaya,
Lezzan Keskin,
Ismet Aydogdu,
İrfan Kuku,
Nilüfer Bayraktar,
MA Erkut
Publication year - 2005
Publication title -
journal of international medical research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.421
H-Index - 57
eISSN - 1473-2300
pISSN - 0300-0605
DOI - 10.1177/147323000503300611
Subject(s) - medicine , abvd , bleomycin , malondialdehyde , superoxide dismutase , glutathione peroxidase , antioxidant , dacarbazine , chemotherapy , gastroenterology , vincristine , lymphoma , pharmacology , cyclophosphamide , oxidative stress , biochemistry , chemistry
This study investigated changing levels of serum oxidant/antioxidant with chemotherapy and their relation to treatment in 34 Hodgkin's lymphoma patients. The patient population consisted of 19 males and 15 females. Mean age was 30.41 ± 12.08 years. All patients received the adriamycin, bleomycin, vincristine and dexamethasone (ABVD) treatment protocol. Blood samples were taken before treatment, and on days 1 and 7 during treatment for measurement of superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), catalase (CAT), malondialdehyde (MDA), nitric oxide (NO) and enzyme activities. After ABVD treatment, mean free radical levels were increased and antioxidant levels were significantly decreased in the serum. ABVD treatment results in an increase of free radical levels and a decrease of antioxidant levels in the serum of patients with Hodgkin's lymphoma.