Open AccessEnhanced Effects of Combined Bu-Zhong-Yi-Qi-Tang (TJ-41) and Interleukin-18 on the Production of Tumour Necrosis Factor-α and Interferon-γ in Human Peripheral Blood Mononuclear Cells
Author(s) -
Ryuji Tamura,
Hisaho Takahashi,
Xue Dong,
Shinichiro Kubo,
Shinnya Saito,
Masahiro Nishibori,
Hiromi Ishibashi,
Noriaki Tanaka
Publication year - 2004
Publication title -
journal of international medical research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.421
H-Index - 57
eISSN - 1473-2300
pISSN - 0300-0605
DOI - 10.1177/147323000403200104
Subject(s) - peripheral blood mononuclear cell , tumor necrosis factor alpha , medicine , interferon gamma , immune system , interleukin , immunology , interferon , cell adhesion molecule , cytokine , interferon γ , necrosis , intracellular , in vitro , microbiology and biotechnology , pathology , biology , biochemistry
Co-stimulatory molecules play important roles in immune responses. We investigated the effect of Bu-Zhong-Yi-Qi-Tang (TJ-41) on the expression of intercellular adhesion molecule-1 (ICAM-1), B7.1 and B7.2 by peripheral blood mononuclear cells stimulated by interleukin-18 (IL-18) using fluorescence-activated cell sorter analysis. TJ-41 increased IL-18-induced ICAM-1 and B7.2 expression, resulting in enhanced production of tumour necrosis factor-a and interferon-g. These results suggest that TJ-41 enhances IL-18-induced cell-mediated immunity and may enhance host defence mechanisms against pathogens.