Association of aldosterone synthase (CYP11B2) -344 T/C polymorphism with diabetic nephropathy: A meta-analysis

Studies on the relation between aldosterone synthase -344 T/C polymorphism and diabetic nephropathy showed controversial conclusions. This meta-analysis aimed to systematically summarize the association between aldosterone synthase (CYP11B2) gene polymorphism and diabetic nephropathy risk.Embase, PubMed, ScienceDirect, Web of Science, Wanfang Data, VIP Database, China Knowledge Resource Integrated Database and SinoMed have been searched. A total of five studies including 825 cases and 910 controls were included.In overall analysis, significant increased risk was found in recessive comparison (OR = 1.27, 95% CI 1.05-1.55), homozygote comparison (OR = 1.39, 95% CI 1.04-1.88) and allele comparison (OR = 1.20, 95% CI = 1.05-1.39). No significant association was detected in dominant comparison (OR = 1.27, 95% CI 0.97-1.66) and heterozygote comparison (OR = 1.17, 95% CI 0.88-1.56). In subgroup analysis, significant increased risk existed in Asian population in allele comparison (OR = 1.45, 95% CI = 1.17-1.79), dominant comparison (OR = 1.78, 95% CI 1.11-2.87), homozygote comparison (OR = 2.11, 95% CI 1.29-3.47), recessive comparison (OR = 1.54, 95% CI 1.17-2.03), except for heterozygote comparison (OR = 1.44, 95% CI 0.87-2.38).Our meta-analysis indicates that aldosterone synthase (CYP11B2) gene polymorphism may contribute to diabetic nephropathy development, especially in Asian group, with the T allele acting as a risk factor.