The insertion and deletion (I28005D) polymorphism of the angiotensin I converting enzyme gene is a risk factor for osteoarthritis in an Asian Indian population | Zendy

Subhadra Poornima | Zendy; Krishna Subramanyam | Zendy; Imran Ali Khan | Zendy; Qurratulain Hasan | Zendy

Open Access

The insertion and deletion (I28005D) polymorphism of the angiotensin I converting enzyme gene is a risk factor for osteoarthritis in an Asian Indian population

Author(s) -

Subhadra Poornima,

Krishna Subramanyam,

Imran Ali Khan,

Qurratulain Hasan

Publication year - 2014

Publication title -

journal of the renin-angiotensin-aldosterone system

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.457

H-Index - 46

eISSN - 1752-8976

pISSN - 1470-3203

DOI - 10.1177/1470320314547403

Subject(s) - genotype , osteoarthritis , allele , angiotensin converting enzyme , gene polymorphism , medicine , polymerase chain reaction , pathogenesis , polymorphism (computer science) , gene , genetics , biology , pathology , blood pressure , alternative medicine

Angiotensin I converting enzyme (ACE) insertion and deletion (I/D) polymorphism has been implicated in the pathogenesis of osteoarthritis (OA). In recent years, numerous genetic factors have been identified and implicated in OA. In this Asian Indian population-based study, we aimed to evaluate the relationship between ACE (I28005D) gene polymorphism and primary OA. We performed a case-control association study to identify and explore the correlation between clinically, radiologically diagnosed individuals with primary knee OA and the ACE I/D polymorphism.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research