The microRNA-132/212 family fine-tunes multiple targets in Angiotensin II signalling in cardiac fibroblasts | Zendy

Tilde Eskildsen | Zendy; Mikael Schneider | Zendy; Maria Boysen Sandberg | Zendy; Vibe Skov | Zendy; Hasse Brønnum | Zendy; Mads Thomassen | Zendy; Torben A. Kruse | Zendy; Ditte Caroline Andersen | Zendy; Søren P. Sheikh | Zendy

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The microRNA-132/212 family fine-tunes multiple targets in Angiotensin II signalling in cardiac fibroblasts

Author(s) -

Tilde Eskildsen,

Mikael Schneider,

Maria Boysen Sandberg,

Vibe Skov,

Hasse Brønnum,

Mads Thomassen,

Torben A. Kruse,

Ditte Caroline Andersen,

Søren P. Sheikh

Publication year - 2014

Publication title -

journal of the renin-angiotensin-aldosterone system

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.457

H-Index - 46

eISSN - 1752-8976

pISSN - 1470-3203

DOI - 10.1177/1470320314539367

Subject(s) - microrna , in silico , angiotensin ii , biology , signalling , microbiology and biotechnology , gene regulatory network , hedgehog signaling pathway , gene , signal transduction , function (biology) , computational biology , bioinformatics , receptor , gene expression , genetics

MicroRNAs (miRNAs) are emerging as key regulators of cardiovascular development and disease; however, the cardiac miRNA target molecules are not well understood. We and others have described the Angiotensin II (AngII)-induced miR-132/212 family as novel regulators of cardiovascular function including regulation of cardiac hypertrophy, heart failure and blood pressure possibly through AT1R signalling. However, the miR-132/212 targets in the heart remain unknown.

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