Association of echocardiographic left ventricular structure and −344C/T aldosterone synthase gene variant: A meta-analysis | Zendy

Lijuan Wang | Zendy; Jiapeng Zhou | Zendy; Bei Zhang | Zendy; Hao Wang | Zendy; Mei Li | Zendy; Qiuli Niu | Zendy; Yubao Chen | Zendy; Runsheng Chen | Zendy; Shaojun Wen | Zendy

Open Access

Association of echocardiographic left ventricular structure and −344C/T aldosterone synthase gene variant: A meta-analysis

Author(s) -

Lijuan Wang,

Jiapeng Zhou,

Bei Zhang,

Hao Wang,

Mei Li,

Qiuli Niu,

Yubao Chen,

Runsheng Chen,

Shaojun Wen

Publication year - 2014

Publication title -

journal of the renin-angiotensin-aldosterone system

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.457

H-Index - 46

eISSN - 1752-8976

pISSN - 1470-3203

DOI - 10.1177/1470320314535459

Subject(s) - aldosterone synthase , medicine , cardiology , left ventricular hypertrophy , odds ratio , confidence interval , aldosterone , interventricular septum , meta analysis , diastole , ventricular remodeling , subgroup analysis , blood pressure , ventricle , heart failure , renin–angiotensin system

Aldosterone synthase (CYP11B2) is one of the most studied candidate genes related to essential hypertension (EH) and left ventricular hypertrophy (LVH). Some studies have focused on the relationship between -344C/T polymorphism (rs1799998) in the CYP11B2 gene and LVH, but the results are controversial. This meta-analysis is purposed to reveal the relationship between the -344C/T and the left ventricular structure and function, including left ventricular end diastolic dimension (LVEDD), left ventricular end systolic diameter (LVESD), left ventricular mass/left ventricular mass index (LVM/LVMI), left ventricular posterior wall thickness (LVPWT), and interventricular septal wall thickness (IVS).

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