Open AccessSpironolactone enhances the beneficial effect of aliskiren on cardiac structural and electrical remodeling in TGR(mRen2)27 rats
Author(s) -
Walmor C. De Mello
Publication year - 2013
Publication title -
jraas. journal of the renin-angiotensin-aldosterone system/journal of the renin-angiotensin-aldosterone system
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.457
H-Index - 46
eISSN - 1752-8976
pISSN - 1470-3203
DOI - 10.1177/1470320313497818
Subject(s) - aliskiren , spironolactone , ventricle , medicine , ejection fraction , aldosterone , cardiology , endocrinology , heart failure , brain natriuretic peptide , renin–angiotensin system , blood pressure
To investigate the influence of simultaneous administration of spironolactone (20 mg/kg per day, intraperitoneal (i.p.)) and aliskiren (50 mg/kg per day, i.p.) for a period of eight weeks on cardiac remodeling in TGR(mRen2)27 rats.