Open AccessPioglitazone enhances the blood pressure-lowering effect of losartan via synergistic attenuation of angiotensin II-induced vasoconstriction
Author(s) -
Xiang Kong,
Mingzhe Ma,
Li Qin,
Yan Zhang,
Xiaoyong Li,
Guodong Wang,
Qing Su,
Dao-you Zhang
Publication year - 2013
Publication title -
jraas. journal of the renin-angiotensin-aldosterone system/journal of the renin-angiotensin-aldosterone system
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.457
H-Index - 46
eISSN - 1752-8976
pISSN - 1470-3203
DOI - 10.1177/1470320313489061
Subject(s) - losartan , pioglitazone , endocrinology , medicine , angiotensin ii , enos , blood pressure , chemistry , p22phox , angiotensin ii receptor type 1 , nadph oxidase , nicotinamide adenine dinucleotide phosphate , valsartan , nitric oxide synthase , pharmacology , nitric oxide , oxidase test , type 2 diabetes , biochemistry , diabetes mellitus , oxidative stress , enzyme
This study was designed to investigate the underlying mechanisms of synergistic antihypertensive effect produced by combination therapy of losartan and pioglitazone in metabolic syndrome (MS) rats.