Open AccessAliskiren alleviates doxorubicin-induced nephrotoxicity by inhibiting oxidative stress and podocyte injury
Author(s) -
Azhar Rashikh,
Krishna Kolappa Pillai,
Shibli Jameel Ahmad,
Mohd Akhtar,
Abul Kalam Najmi
Publication year - 2012
Publication title -
journal of the renin-angiotensin-aldosterone system
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.457
H-Index - 46
eISSN - 1752-8976
pISSN - 1470-3203
DOI - 10.1177/1470320312459980
Subject(s) - aliskiren , nephrotoxicity , pharmacology , chemistry , oxidative stress , malondialdehyde , podocyte , glomerular basement membrane , kidney , doxorubicin , creatinine , endocrinology , medicine , renin–angiotensin system , chemotherapy , biochemistry , blood pressure , glomerulonephritis , proteinuria
Doxorubicin (DXR) is one of the most effective and widely used anthracycline antibiotics. However, its clinical application is hampered by toxic effects in many organs. Nephrotoxicity is one of the major side effects of anthracycline antibiotics. This study was designed to investigate the possible protective effects of aliskiren (a direct renin inhibitor) in DXR-induced nephrotoxicity in rats.
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