Open AccessRelationship between −344T/C polymorphism in the aldosterone synthase gene and atrial fibrillation in patients with essential hypertension
Author(s) -
SU Xiao-jian,
Jun Yang,
Xiaohong Hou,
Jun Li,
Yu Shi,
Yanyan Jing
Publication year - 2011
Publication title -
jraas. journal of the renin-angiotensin-aldosterone system/journal of the renin-angiotensin-aldosterone system
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.457
H-Index - 46
eISSN - 1752-8976
pISSN - 1470-3203
DOI - 10.1177/1470320311417654
Subject(s) - aldosterone synthase , medicine , allele , genotype , atrial fibrillation , aldosterone , polymorphism (computer science) , endocrinology , essential hypertension , pathogenesis , gene , biology , genetics , renin–angiotensin system , blood pressure
Aldosterone plays an important role in the pathogenesis of non-familial atrial fibrillation (AF). We tested the hypothesis that the −344T/C polymorphism in the aldosterone synthase gene may be associated with non-familial AF in Chinese patients with hypertension. Materials and methods: We performed a 1:1 paired case–control study in 310 cases of hypertension with AF and same number matched controls. The −344T/C polymorphism was determined with polymerase chain reaction–restriction fragment length polymorphism. Results: The distribution of the CYP11B2 genotypes (TT, TC and CC) was 41.9%, 50.6%, and 7.4% in AF patients, which was not different from controls (48.4%, 44.5%, and 7.1%, χ 2 = 2.675, p = 0.263). The difference between the C allele (32.3% vs. 29.4%) was also not significant between two groups (χ 2 = 1.661, p = 0.197). Logistic regression analysis showed that LAD and LVEDD (both p < 0.001), rather than the C allele of the CYP11B2 gene ( p= 0.107) were significant predictors for AF. The LAD of C allele carriers is significantly larger than that of non-C allele carriers ( p = 0.009). Conclusions: Our results indicate that the −344T/C polymorphism in the aldostrone synthase gene is not associated with AF but it might be associated with atrial remodelling in hypertensives.