Open AccessAssociation of angiotensin I converting enzyme insertion/deletion polymorphism with breast cancer: a meta-analysis
Author(s) -
Meili Sun,
Chuanyong Liu,
Wei Fang,
Jie Zhong,
Ying Sun
Publication year - 2011
Publication title -
jraas. journal of the renin-angiotensin-aldosterone system/journal of the renin-angiotensin-aldosterone system
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.457
H-Index - 46
eISSN - 1752-8976
pISSN - 1470-3203
DOI - 10.1177/1470320311405699
Subject(s) - breast cancer , odds ratio , genotype , confidence interval , meta analysis , angiotensin converting enzyme , medicine , oncology , cancer , gene , genetics , biology , blood pressure
Background: Polymorphisms of angiotensin I converting enzyme (ACE) gene have been inconsistently associated with breast cancer risk. We examined these associations by performing a meta-analysis. Materials and methods: Four studies (cases: 1422; controls: 3044) testing the association between ACE insertion/deletion (I/D) polymorphism and breast cancer were examined. The analyses were performed using the Review Manager 5.0.25 software package. Results: The combined results based on the above four studies showed that there was no significant difference in genotype distribution (DD, ID or II) between breast cancer patients and controls, with the odds ratio (OR) (1.00; 0.94; 1.11) and 95% confidence interval (CI) (0.76 to 1.33; 0.83 to 1.07; 0.96 to 1.28) for DD, ID and II genotype respectively. Conclusion: The meta-analysis suggests that ACE I/D polymorphism may not be a genetic risk factor for breast cancer.