Open AccessInflammatory Response on the Pancreatic Acinar Cell Injury
Author(s) -
Madhav Bhatia
Publication year - 2005
Publication title -
scandinavian journal of surgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.774
H-Index - 50
eISSN - 1799-7267
pISSN - 1457-4969
DOI - 10.1177/145749690509400203
Subject(s) - medicine , acute pancreatitis , systemic inflammatory response syndrome , pancreatitis , multiple organ dysfunction syndrome , inflammation , pathogenesis , organ dysfunction , acinar cell , gastroenterology , sepsis
Acute pancreatitis is an inflammatory disorder, and inflammation not only affects the pathogenesis but also the course of the disease. Acinar cell injury early in acute pancreatitis leads to a local inflammatory reaction; if marked this leads to a systemic inflammatory response syndrome (SIRS). An excessive SIRS leads to distant organ damage and multiple organ dysfunction syndrome (MODS). MODS associated with acute pancreatitis is the primary cause of morbidity and mortality in this condition. Recent studies by us and other investigators have established the critical role played by inflammatory mediators such as TNF-α, IL-1β, IL-6, IL-8, CINC/GRO-α, MCP-1, PAF, IL-10, CD40L, C5a, ICAM-1, MIP1-α, RANTES, substance P, and hydrogen sulfide in acute pancreatitis and the resultant MODS. This review intends to present an overview of the inflammatory response that takes place following pancreatic acinar cell injury.