QUANTITATIVE ANALYSIS OF THE ESTERASES IN RAT MEGAKARYOCYTES BY A RADIO-ISOTOPE CYTOCHEMICAL TECHNIQUE | Zendy

Zbigniew Darżynkiewicz | Zendy; Andrew W. Rogers | Zendy; Eric A. Barnard | Zendy

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QUANTITATIVE ANALYSIS OF THE ESTERASES IN RAT MEGAKARYOCYTES BY A RADIO-ISOTOPE CYTOCHEMICAL TECHNIQUE

Author(s) -

Zbigniew Darżynkiewicz,

Andrew W. Rogers,

Eric A. Barnard

Publication year - 1966

Publication title -

journal of histochemistry and cytochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.971

H-Index - 124

eISSN - 1551-5044

pISSN - 0022-1554

DOI - 10.1177/14.5.379

Subject(s) - chemistry , isotope , cytochemistry , pyridine , bone marrow , biochemistry , megakaryocyte , radiochemistry , microbiology and biotechnology , biology , enzyme , immunology , organic chemistry , haematopoiesis , physics , quantum mechanics , stem cell

Megakaryocytes from bone marrow of immature rats have been treated with 3 H-DFP, and the grain density over them measured in autoradiographs. The uptake of labeled DFP is reduced by one-third by eserine and by the AChase inhibitor 284C51, and by reactivation with pyridine-2-aldoxime. It is concluded that one-third of the DFP taken up by megakaryocytes represents binding to true AChase. The other esterases present include no significant amount of pseudocholinesterase.

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