RIBONUCLEASE ACTIVITY OF PERIPHERAL LEUCOCYTES AND SERUM IN RABIES-SUSCEPTIBLE AND RABIES-REFRACTORY MICE | Zendy

J. B. Enright | Zendy; Fredric L. Frye | Zendy; Onkar S. Atwal | Zendy

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RIBONUCLEASE ACTIVITY OF PERIPHERAL LEUCOCYTES AND SERUM IN RABIES-SUSCEPTIBLE AND RABIES-REFRACTORY MICE

Author(s) -

J. B. Enright,

Fredric L. Frye,

Onkar S. Atwal

Publication year - 1965

Publication title -

journal of histochemistry and cytochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.971

H-Index - 124

eISSN - 1551-5044

pISSN - 0022-1554

DOI - 10.1177/13.6.515

Subject(s) - rabies , rabies virus , ribonuclease , virulence , biology , refractory (planetary science) , peripheral blood , virology , extracellular , enzyme , immunology , rna , genetics , biochemistry , gene , astrobiology

Comparative data are presented on the intra- and extracellular concentrations of blood ribonuclease in two different strains of mice; one rabies-susceptible, the other rabies-refractory. The coincidence of finding a higher extracellular level of the enzyme in the rabies-refractory group is discussed in its possible relationship to mechanisms of host susceptibility and resistance to virulent rabies virus. The probable genetic basis for the differences in enzyme localization is also discussed.

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