Open AccessA Clinician’s Guide to Topical Retinoids
Author(s) -
Melika Motamedi,
Ahmad Chehade,
Ravina Sanghera,
Parbeer Grewal
Publication year - 2021
Publication title -
journal of cutaneous medicine and surgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.593
H-Index - 47
eISSN - 1615-7109
pISSN - 1203-4754
DOI - 10.1177/12034754211035091
Subject(s) - retinoid , medicine , retinoic acid , tretinoin , receptor , isotretinoin , pharmacology , computational biology , bioinformatics , dermatology , biochemistry , biology , acne , gene
Retinoids are defined as molecules that bind to and activate retinoic acid receptors to influence the proliferation and differentiation of cells. Topical retinoids have evolved over the past several decades, being used in multiple dermatological conditions. This review aims to differentiate between synthetic and natural retinoids, discuss the pharmacology behind topical retinoids, highlight clinical applications, and categorize all the commercially available agents, including combination products. Understanding retinoid affinities for unique receptor subtypes can impact clinical decisions, resulting in optimizing treatment and enhancing patient adherence.