TETRACYCLINE FLUORESCENCE IN MOUSE GASTRIC CARCINOMA | Zendy

Yoshiro Yabe | Zendy; Irving A. Warren | Zendy; J. Edward Berk | Zendy; Sidney D. Kobernick | Zendy

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TETRACYCLINE FLUORESCENCE IN MOUSE GASTRIC CARCINOMA

Author(s) -

Yoshiro Yabe,

Irving A. Warren,

J. Edward Berk,

Sidney D. Kobernick

Publication year - 1964

Publication title -

journal of histochemistry and cytochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.971

H-Index - 124

eISSN - 1551-5044

pISSN - 0022-1554

DOI - 10.1177/12.11.842

Subject(s) - tetracycline , cytoplasm , fluorescence , pathology , fluorescence microscope , adenocarcinoma , stroma , carcinoma , parenchyma , biology , chemistry , microbiology and biotechnology , cancer , medicine , immunohistochemistry , antibiotics , biochemistry , physics , quantum mechanics , genetics

Tetracycline was administered to a strain of C57BL mouse harboring an experimental and transmissible tumor, gastric adenocarcinoma No. 328. Using fluorescent and phase microscopy, the fluorescence induced by the drug was localized to the cytoplasm of the tumor cells and to the cytoplasm of normal gastric mucosal and liver parenchymal cells. None was observed in the stroma. The fluorescence appeared rapidly but was retained by the tumor and normal cells for only 48 to 72 hours in contrast to the long lasting fluorescence present in bone and teeth, and that observed in some patients with carcinoma.

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