Open AccessDelayed Bladder Perforation Related to Immediate Single Dose Intravesical Doxorubicin Instillation After TURBT: A Case Report and Literature Review
Author(s) -
Adel Alrabadi,
Mohannad Abuhamad,
Hammam Mansi,
Sohaib Alhamss,
Nadwa Bustami,
Saddam Al Demour,
Mousa A. AlAbbadi
Publication year - 2021
Publication title -
clinical medicine insights. case reports
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.187
H-Index - 12
ISSN - 1179-5476
DOI - 10.1177/1179547620986158
Subject(s) - medicine , bladder cancer , doxorubicin , perforation , conservative management , surgery , case presentation , bladder tumor , resection , complication , urinary bladder , chemotherapy , presentation (obstetrics) , urology , cancer , materials science , punching , metallurgy
Intravesical chemotherapy instillation immediately after tumor resection is a well-known practice in the management of non-muscle invasive bladder cancer. Despite being largely well tolerated in most cases, it is not devoid of severe and life-threatening complications.Case Presentation: We present an unusual case of bladder perforation that happened 2 weeks after bladder tumor resection. The patient had received single dose intra-vesical instillation of doxorubicin after TUR-BT. Conservative managements failed to achieve bladder healing; as a result, open surgical repair was performed. To the best of our knowledge, this is the first reported case of bladder perforation after intra-vesical doxorubicin instillation.Conclusion: The occurrence of such a rare serious complication in a mostly safe intervention must be taken into consideration. A high index of suspicion, timely management, and proceeding to more invasive surgical treatments when necessary are cornerstones in the management and preserving the bladder.