Neurodegeneration, Heterochromatin, and Double-Stranded RNA | Zendy

Saldi Tassa K | Zendy; Gonzales Patrick K | Zendy; LaRocca Thomas J | Zendy; Link Christopher D | Zendy

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Neurodegeneration, Heterochromatin, and Double-Stranded RNA

Author(s) -

Saldi Tassa K,

Gonzales Patrick K,

LaRocca Thomas J,

Link Christopher D

Publication year - 2019

Publication title -

journal of experimental neuroscience

Language(s) - English

Resource type - Journals

ISSN - 1179-0695

DOI - 10.1177/1179069519830697

Subject(s) - neurodegeneration , heterochromatin , epigenetics , chromatin , biology , derepression , neuroscience , innate immune system , disease , rna , neuroinflammation , genetics , medicine , immune system , gene expression , immunology , psychological repression , inflammation , gene , pathology

Changes in chromatin and epigenetic modifications have been associated with aging and aging-associated neurodegenerative diseases, although the causal relationship between these changes and disease-related pathology has been unclear. Recent studies have now made direct connections between neurodegeneration-associated proteins and derepression of repetitive element transcription due to changes in heterochromatin. We suggest that this derepression leads to an increased accumulation of intracellular double-stranded RNA (dsRNA), with an attendant induction of innate immune responses that contribute to the neuroinflammation found in essentially all age-associated neurodegenerative diseases.

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