Comparative Co-Evolution Analysis Between the HA and NA Genes of Influenza A Virus | Zendy

Jinhwa Jang | Zendy; Se-Eun Bae | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Comparative Co-Evolution Analysis Between the HA and NA Genes of Influenza A Virus

Author(s) -

Jinhwa Jang,

Se-Eun Bae

Publication year - 2018

Publication title -

virology research and treatment

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.765

H-Index - 10

ISSN - 1178-122X

DOI - 10.1177/1178122x18788328

Subject(s) - biology , hemagglutinin (influenza) , gene , phylogenetic tree , neuraminidase , virus , virology , host (biology) , influenza a virus subtype h5n1 , genetics , influenza a virus , phylogenetics , h5n1 genetic structure , covid-19 , medicine , disease , pathology , infectious disease (medical specialty)

Influenza A virus subtypes are determined based on envelope proteins encoded by the hemagglutinin (HA) gene and the neuraminidase (NA) gene, which are involved in attachment to the host, pathogenicity, and progeny production. Here, we evaluated such differences through co-evolution analysis between the HA and NA genes based on subtype and host. Event-based cophylogeny analysis revealed that humans had higher cospeciation values than avian. In particular, the yearly ML phylogenetic trees for the H1N1 and H3N2 subtypes in humans displayed similar topologies between the two genes in humans. Substitution analysis was verifying the strong positive correlation between the two genes in the H1N1 and H3N2 subtypes in humans compared with those in avian and swine. These results provided a proof of principle for the further development of vaccines according to hosts and subtypes against Influenza A virus.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research