Diversified Variants of Astrovirus MLB2 in Patients Following Hematopoietic Stem Cell Transplantation and the Evolutionary Rates and Patterns of the Virus | Zendy

Guo Ke | Zendy; Li Li-Li | Zendy; Zhang Qing | Zendy; Yu Jie-Mei | Zendy; Ye Yan | Zendy

Open Access

Diversified Variants of Astrovirus MLB2 in Patients Following Hematopoietic Stem Cell Transplantation and the Evolutionary Rates and Patterns of the Virus

Author(s) -

Guo Ke,

Li Li-Li,

Zhang Qing,

Yu Jie-Mei,

Ye Yan

Publication year - 2019

Publication title -

evolutionary bioinformatics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.502

H-Index - 32

ISSN - 1176-9343

DOI - 10.1177/1176934319864922

Subject(s) - astrovirus , viral quasispecies , hematopoietic stem cell transplantation , transplantation , virus , stem cell , biology , population , haematopoiesis , virology , medicine , genetics , hepatitis c virus , environmental health , rotavirus

We assessed the quasispecies heterogeneity of a human astrovirus MLB2 (HAstV-MLB2-YJMGK) in immunocompromised patients following hematopoietic stem cell transplantation and performed genetic and evolutionary analyses of HAstV isolates circulating worldwide. The result showed that the virus had diversified variants and a strong positive selection in the patient, indicating that such patients may be a reservoir for astrovirus. The time to the most recent common ancestor of MLB2 and classic HAstVs was around 1800 years, and it has a decline in effective population size of HAstVs in the late 100 years.

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