HISTOCHEMICAL EVIDENCE OF PROTEOLYSIS IN BONE: THE INFLUENCE OF PARATHORMONE | Zendy

Leonard F. Bélanger | Zendy; B. B. Migicovsky | Zendy

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HISTOCHEMICAL EVIDENCE OF PROTEOLYSIS IN BONE: THE INFLUENCE OF PARATHORMONE

Author(s) -

Leonard F. Bélanger,

B. B. Migicovsky

Publication year - 1963

Publication title -

journal of histochemistry and cytochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.971

H-Index - 124

eISSN - 1551-5044

pISSN - 0022-1554

DOI - 10.1177/11.6.734

Subject(s) - chemistry , proteolysis , trichloroacetic acid , gelatin , acetic acid , formaldehyde , fixation (population genetics) , ethanol , biochemistry , sodium fluoride , bone resorption , sodium , fluoride , medicine , chromatography , endocrinology , enzyme , biology , inorganic chemistry , organic chemistry , gene

Proteolytic activity has been revealed at the level of the large osteocytes of young chick and rat bone by digestion of gelatin in a photographic emulsion substrate. The reaction was enhanced by pretreatment of the animals with parathyroid extract. The reaction was inhibited by addition to the incubating medium of sodium fluoride or potassium ferrocyanide. It was also inhibited by fixation in ethanol-formaldehyde acetic acid. The present results seem to confirm and explain further the resorptive potential of the mature osteocytes.

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