Open AccessSafety Assessment of Fatty Acid Amidopropyl Dimethylamines as Used in Cosmetics
Author(s) -
Christina L. Burnett,
Ivan Boyer,
Wilma F. Bergfeld,
D. Belsito,
Ronald A. Hill,
Curtis D. Klaassen,
D.C. Liebler,
James G. Marks,
Ronald C. Shank,
Thomas J. Slaga,
Paul W. Snyder,
Lillian J. Gill,
Bart Heldreth
Publication year - 2019
Publication title -
international journal of toxicology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 58
eISSN - 1092-874X
pISSN - 1091-5818
DOI - 10.1177/1091581819836089
Subject(s) - cosmetics , fatty acid , antistatic agent , toxicology , chemistry , medicine , food science , organic chemistry , biology , layer (electronics)
The Cosmetic Ingredient Review Expert Panel (Panel) reviewed the safety of fatty acid amidopropyl dimethylamines, which function primarily as antistatic agents in cosmetic products. The relevant animal and human data reviewed for these ingredients indicate that they are potential dermal sensitizers that may be due in part by the sensitizing impurity, 3,3-dimethylaminopropylamine. The Panel concluded that fatty acid amidopropyl dimethylamines were safe as cosmetic ingredients when they are formulated to be nonsensitizing, which may be based on a quantitative risk assessment.
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