Biomarkers of Endothelial, Renal, and Platelet Dysfunction in Stage 5 Chronic Kidney Disease Hemodialysis Patients With Heart Failure | Zendy

Ryan P. McMillan | Zendy; Leonidas Skiadopoulos | Zendy; Debra Hoppensteadt | Zendy; Nil Güler | Zendy; Vinod Bansal | Zendy; Ravipresenna Parasuraman | Zendy; Jawed Fareed | Zendy

Open Access

Biomarkers of Endothelial, Renal, and Platelet Dysfunction in Stage 5 Chronic Kidney Disease Hemodialysis Patients With Heart Failure

Author(s) -

Ryan P. McMillan,

Leonidas Skiadopoulos,

Debra Hoppensteadt,

Nil Güler,

Vinod Bansal,

Ravipresenna Parasuraman,

Jawed Fareed

Publication year - 2017

Publication title -

clinical and applied thrombosis/hemostasis

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.643

H-Index - 53

eISSN - 1938-2723

pISSN - 1076-0296

DOI - 10.1177/1076029617729216

Subject(s) - medicine , hemodialysis , endothelial dysfunction , cardiology , kidney disease , stage (stratigraphy) , heart failure , disease , platelet , chronic renal failure , biology , paleontology

The aim of this study was to determine the role of endothelial, renal, and inflammatory biomarkers in the pathogenesis of heart failure (HF) in patients with stage 5 chronic kidney disease (CKD5) undergoing maintenance hemodialysis (HD). Plasma levels of biomarkers-kidney injury molecule 1 (KIM-1), N-terminal pro brain natriuretic peptide (NT-proBNP), glycated hemoglobin, neutrophil gelatinase-associated lipocalin, interleukin-18,platelet-derived growth factor, platelet factor 4 (PF4), 25-OH vitamin D, parathyroid hormone (PTH), endothelin, and endocan-were measured in CKD5-HD patients at the Loyola University Ambulatory Dialysis facility. The HF (+) CKD5-HD patients, as compared to HF (-) CKD5-HD patients, exhibited significantly elevated NT-proBNP ( P = .0194) and KIM-1 ( P = .0485). The NT-proBNP in HF (+) CKD5-HD patients was found to correlate with the levels of serum potassium ( P = .023, R = -.39), calcium ( P = .029, R = -.38), and PF4 ( P = .045, R = -.35). The KIM-1 in HF (+) CKD5-HD patients was found to correlate with PTH ( P = .043, R = -.36) and 25-OH vitamin D ( P = .037, R = .36). Elevated plasma NT-proBNP and KIM-1 in CKD5-HD and HF (+) CKD5-HD patients suggest that natriuretic peptides and KIM-1 may contribute to the pathogenesis of HF in CKD5-HD patients.

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