Open AccessProtocolled Redefinition of the Therapeutic Range for Unfractionated Heparin: Lost in Translation?
Author(s) -
Karlien L. M. Coene,
Fedde van der Graaf,
Daan van de Kerkhof
Publication year - 2016
Publication title -
clinical and applied thrombosis/hemostasis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.643
H-Index - 53
eISSN - 1938-2723
pISSN - 1076-0296
DOI - 10.1177/1076029616679508
Subject(s) - therapeutic index , medicine , nomogram , heparin , partial thromboplastin time , therapeutic effect , population , therapeutic drug monitoring , intensive care medicine , pharmacology , coagulation , pharmacokinetics , drug , environmental health
Protocolled treatment with unfractionated heparin (UFH) is a subject of ongoing debate. Even though international guidelines prescribe calibration of the activated partial thromboplastin time (aPTT) to 0.3 to 0.7 U/mL anti-Xa activity to establish an UFH therapeutic range, evidence for this approach remains scarce. In this study, we evaluated different strategies to delineate the UFH therapeutic range and analyzed the effects on patient therapeutic classification.
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom