Open AccessAssociation Between Neutrophil to Lymphocyte Ratio and Severity of Coronary Artery Disease
Author(s) -
Hasan Kaya,
Faruk Ertaş,
Yahya İslamoğlu,
Zekeriya Kaya,
Zuhal Arıtürk Atılgan,
Habib Çil,
Ahmet C̨alışkan,
Mesut Aydın,
Mustafa Oylumlu,
Mehmet Serdar Soydinç
Publication year - 2012
Publication title -
clinical and applied thrombosis/hemostasis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.643
H-Index - 53
eISSN - 1938-2723
pISSN - 1076-0296
DOI - 10.1177/1076029612452116
Subject(s) - medicine , coronary atherosclerosis , cardiology , coronary artery disease , neutrophil to lymphocyte ratio , coronary angiography , multivariate analysis , lymphocyte , stenosis , artery , myocardial infarction
The aim of this study is to investigate the association between neutrophil to lymphocyte ratio (NLR) and severity of coronary atherosclerosis. A total of 172 patients undergoing coronary angiography were included in the study. Control group consisted of patients with normal coronary arteries. Patients with coronary stenosis were divided into 2 groups by use of Gensini scores. The NLR was higher in severe atherosclerosis group compared with mild atherosclerosis and control groups ( P < .001). In correlation analysis, NLR showed significant correlation with Gensini score. A cutoff value of 2.5 for NLR predicted severe atherosclerosis with a sensitivity and specificity of 62% and 69%, respectively. After multivariate analysis, high levels of NLR were independent predictors of severe atherosclerosis together with glucose and high-density lipoprotein. Our study suggests that the NLR is a predictor of severe atherosclerosis that may be useful for cardiac risk stratification in patients with coronary artery disease.