Open AccessNT‐Pro Brain Natriuretic Peptide: Is it a New Indicator of Brain Oedema?
Author(s) -
Cetin GN,
Albayrak SB,
Yolcu S,
Senol N,
Tomruk O
Publication year - 2014
Publication title -
hong kong journal of emergency medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.145
H-Index - 12
eISSN - 2309-5407
pISSN - 1024-9079
DOI - 10.1177/102490791402100306
Subject(s) - medicine , brain edema , brain natriuretic peptide , n terminal pro brain natriuretic peptide , natriuretic peptide , prohormone , cardiology , anesthesia , heart failure , hormone
Objective To assess the role of the N‐terminal prohormone form of brain natriuretic peptide (NT‐proBNP) in patients with acute brain oedema. Methods This is a case control study. Twenty‐two patients with acute brain oedema evidenced by computed tomography (CT) were recruited and compared to a control group of 30 healthy adult volunteers. Levels of NT‐proBNP were measured in all patients at hospital admission and on the 12th and 24th hours after admission; as well as in a control group of 30 healthy blood donors. Results Twenty‐two patients with brain oedema and 30 controls were included. There were significant differences between the brain oedema group and the control group on the NT‐proBNP levels at admission time, on 12th or 24th hours after admission. There was no significant difference in NT‐proBNP levels at admission time with the severity of brain oedema evidenced by CT. When we considered the relationship between mannitol usage and NT‐proBNP levels, we found a significant difference between brain oedema severity and NT‐proBNP level according to brain oedema severity after anti‐oedema treatment, for 12th and 24th hours NT‐proBNP levels. Conclusions There is a possible association between brain oedema and elevated serum NT‐proBNP levels. (Hong Kong j.emerg.med. 2014;21:167‐171)