Open AccessEffective Dose of Remifentanil for Control of Haemodynamic Response to Insertion of the Streamlined Liner of the Pharyngeal Airway
Author(s) -
Kim WJ,
Kang H,
Yang SY,
Shin HY,
Baek CW,
Jung YH,
Woo YC,
In JY
Publication year - 2013
Publication title -
hong kong journal of emergency medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.145
H-Index - 12
eISSN - 2309-5407
pISSN - 1024-9079
DOI - 10.1177/102490791302000404
Subject(s) - remifentanil , medicine , anesthesia , hemodynamics , saline , confidence interval , heart rate , blood pressure , airway , propofol
Objective To determine the dose of remifentanil needed to achieve successful insertion of the Streamlined Liner of the Pharyngeal Airway (SLIPA™) without the development of hypertension in 95% of the patients. Design Randomised controlled trial. Setting operating theatre of a university hospital Methods A total of 100 ASA I or II patients requiring SLIPA insertion were randomly assigned to receive normal saline (Group C) or one of the four different doses (0.5 µg/kg [Group R0.5], 1.0 µg/kg [Group R1], 1.5 µg/kg [Group R1.5] or 2.0 µg/kg [Group R2]) of remifentanil. Arterial blood pressure and heart rate were recorded at preanesthetic baseline, preinserton, and every one minute during the initial 3 minutes period after insertion. Results A Probit model of remifentanil concentration was predictive of successful insertion of SLIPA without the development of hypertension. The ED95 of remifentanil needed to suppress haemodynamic response from SLIPA insertion was 1.39 µg/kg (95% confidence interval, 1.06‐2.61 µg/kg). Conclusions A single administration of remifentanil can effectively suppress haemodynamic changes due to the insertion of SLIPA.