Open AccessMitogen‐activated protein kinase pathways in sepsis treatment
Author(s) -
Wang YH,
Liu Y,
Zhou RB
Publication year - 2012
Publication title -
hong kong journal of emergency medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.145
H-Index - 12
eISSN - 2309-5407
pISSN - 1024-9079
DOI - 10.1177/102490791201900507
Subject(s) - sepsis , mapk/erk pathway , medicine , protein kinase a , signal transduction , inflammation , mitogen activated protein kinase , proinflammatory cytokine , immunology , kinase , pathogenesis , nf κb , cytokine , microbiology and biotechnology , cancer research , biology
Sepsis is a characteristic set of systemic reactions to overwhelming infection that remains a major cause of death in critically ill patients. Endotoxins or lipopolysaccharides from gram‐negative bacteria play a major role in the pathogenesis by inducing an over‐production of inflammatory cytokines, which usually triggers beneficial inflammatory responses but causes tissue injury and lethal multiple organ failure in excessive amounts. The production of inflammatory cytokines depends on the activation of many intracellular signaling pathways, including nuclear factor‐κB (NF‐κB) pathway and three mitogen‐activated protein kinase (MAPK) pathways. This review of important MAPK pathways underscores the essential role of MKP‐1 in the negative control of sepsis. Herein is a summary of the roles of MAPK pathways in the production of inflammatory cytokines and the possibility of targeting these pathways for the treatment of sepsis.