AN AUTORADIOGRAPHIC STUDY OF THE LOCALIZATION AND DISTRIBUTION OF TRITIATED HISTIDINE IN BONE | Zendy

E. A. Tonna | Zendy; E. P. Cronkite | Zendy; Mildred Pavelec | Zendy

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AN AUTORADIOGRAPHIC STUDY OF THE LOCALIZATION AND DISTRIBUTION OF TRITIATED HISTIDINE IN BONE

Author(s) -

E. A. Tonna,

E. P. Cronkite,

Mildred Pavelec

Publication year - 1962

Publication title -

journal of histochemistry and cytochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.971

H-Index - 124

eISSN - 1551-5044

pISSN - 0022-1554

DOI - 10.1177/10.5.601

Subject(s) - histidine , tritium , intracellular , chemistry , distribution (mathematics) , amino acid , bone matrix , cartilage , biochemistry , metabolism , microbiology and biotechnology , medicine , biology , anatomy , mathematical analysis , physics , mathematics , nuclear physics

The localization, distribution and cellular turnover of tritium labeled-histidine was followed autoradiographically in the femora of young mice. Initially the labeled amino acid was taken up by the cellular phase of the skeletal system within the first hour after isotope administration. From 1 to 4 hours, intracellular histidine appeared within newly deposited cartilage and bone matrix. By 14 days skeletal cells had lost their label, however, red blood cells were still labeled at 14 days.

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