Open AccessThe Roles of γδ T Cells in Hematopoietic Stem Cell Transplantation
Author(s) -
Wanyi Ye,
Xueting Kong,
Wenbin Zhang,
Zheng Weng,
Xiuli Wu
Publication year - 2020
Publication title -
cell transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.043
H-Index - 100
eISSN - 1555-3892
pISSN - 0963-6897
DOI - 10.1177/0963689720966980
Subject(s) - hematopoietic stem cell transplantation , immune system , immunology , stem cell , haematopoiesis , transplantation , graft versus host disease , t cell , biology , medicine , cancer research , microbiology and biotechnology
The αβ T-cell-depleted hematopoietic stem cell transplantation (HSCT) leads to lower relapse and better outcome, and may correlate strongly with expansion of donor-derived γδ T cells. γδ T cells play an important role in immune reconstitution and can exert a graft-versus-leukemia effect after HSCT. This review showed the recent literature on immune functions of γδ T cells after HSCT. The discrepancies between studies of γδ T cells in graft-versus-host disease may cause by its heterogeneous and various distinct subsets. And reconstitution of γδ T cells may play a potential immunoregulatory role in the infections after HSCT.
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