Successful Use of Combined Intraperitoneal Azlocillin and Aminogl Ycoside in the Treatment of Dialysis Associated Pseudomonas Peritonitis | Zendy

Leung Anthony C.T. | Zendy; Orange Gillian | Zendy; Henderson Lain S. | Zendy; Sleigh J. Douglas | Zendy

Open Access

Successful Use of Combined Intraperitoneal Azlocillin and Aminogl Ycoside in the Treatment of Dialysis Associated Pseudomonas Peritonitis

Author(s) -

Leung Anthony C.T.,

Orange Gillian,

Henderson Lain S.,

Sleigh J. Douglas

Publication year - 1984

Publication title -

peritoneal dialysis international

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.79

H-Index - 83

eISSN - 1718-4304

pISSN - 0896-8608

DOI - 10.1177/089686088400400212

Subject(s) - azlocillin , peritonitis , medicine , peritoneal dialysis , aminoglycoside , antibiotics , nephrotoxicity , antimicrobial , pseudomonas , microbiology and biotechnology , pseudomonas aeruginosa , toxicity , piperacillin , bacteria , biology , genetics

Pseudomonas peritonitis associated with peritoneal dialysis is usually severe and difficult to treat. Prolonged courses of aminoglycoside antibiotics carry the risk of ototoxicity and nephrotoxicity. Azlocillin, a new acylureidopenicillin with potent antipseudomonal activity, was used successfully in combination with an aminoglycoside in the treatment of two patients with dialysis -associated pseudomonas peritonitis. Serum and peritoneal fluid antibiotic levels were monitored and a marked synergistic effect was observed with this antimicrobial combination. Azlocillin may have a useful aminoglycosidesparing effect in the treatment of pseudomonas peritonitis.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research