Melatonin Administration Methods for Research in Mammals and Birds | Zendy

Dax Ovid | Zendy; Tyrone B. Hayes | Zendy; George E. Bentley | Zendy

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Melatonin Administration Methods for Research in Mammals and Birds

Author(s) -

Dax Ovid,

Tyrone B. Hayes,

George E. Bentley

Publication year - 2018

Publication title -

journal of biological rhythms

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.484

H-Index - 101

eISSN - 1552-4531

pISSN - 0748-7304

DOI - 10.1177/0748730418795802

Subject(s) - melatonin , transdermal , hormone , circadian rhythm , silastic , endocrine system , administration (probate law) , biology , pharmacology , medicine , physiology , endocrinology , political science , law

Endocrine research in animals often entails exogenous hormone administration. Special issues arise when developing administration protocols for hormones with circadian and seasonal periodicity. This article reviews various methods for the exogenous administration of hormones with such periodicities by focusing on melatonin. We discuss that methodological variations across studies can affect experimental results. Melatonin administration techniques used in vertebrates includes infusion pumps, beeswax pellets, oral administration, injections, SILASTIC capsules, osmotic pumps, transdermal delivery, beads, and sponges.

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