Open AccessAngiogenesis in bronchial asthma
Author(s) -
Krzysztof Pałgan,
Zbigniew Bartuzi
Publication year - 2015
Publication title -
international journal of immunopathology and pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.724
H-Index - 53
eISSN - 2058-7384
pISSN - 0394-6320
DOI - 10.1177/0394632015580907
Subject(s) - angiogenesis , vascularity , medicine , hypervascularity , asthma , airway , vascular endothelial growth factor , vascular remodelling in the embryo , pathology , hyperplasia , neovascularization , inflammation , immunology , vegf receptors , surgery
Bronchial asthma is a chronic inflammatory disease characterised by airflow obstruction that may be reversed spontaneously or in response to treatment. The airway inflammation can lead to structural changes and remodelling consisting of subepithelial layer thickening, airway smooth muscle hyperplasia and angiogenesis. Subepithelial hypervascularity and angiogenesis in the airways are part of the structural airway wall in asthma. Increased vascularity of bronchial mucosa is closely related to the expression of angiogenic factors like vascular endothelial growth factor (VEGF), angiopoietin and hypoxia-inducible factor (HIF). The scope of the present review is to summarise the roles of anagiogenic factors and treatment in vascular development.