Open AccessExpression of Gelatinases (MMP-2, MMP-9) in Human Articular Cartilage
Author(s) -
Luana Lipari,
Aldo Gerbino
Publication year - 2013
Publication title -
international journal of immunopathology and pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.724
H-Index - 53
eISSN - 2058-7384
pISSN - 0394-6320
DOI - 10.1177/039463201302600331
Subject(s) - matrix metalloproteinase , gelatinases , osteoarthritis , cartilage , synovitis , immunohistochemistry , medicine , pathology , articular cartilage , arthritis , anatomy , gelatinase , alternative medicine
Osteoarthritis (OA) is a chronic degenerative joint disorder characterized by destruction of the articular cartilage, subchondral bone alterations and synovitis. Matrix metalloproteinases (MMPs) are expressed in joint tissues of patients with osteoarthritis (OA). The objective of this study was to define the steady state levels of two different MMPs to provide more insight into the role of MMPs in cartilage destruction in OA. We investigated the expression of gelatinases through immunohistochemistry Our results show that high levels of MMP-2 and MMP-9 are present in OA and suggest that once these MMPs are fully activated they may contribute to the cartilage destruction in OA.
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