Open AccessSystemic Lupus Erythematosus: Immunopathogenesis and Novel Therapeutic Targets
Author(s) -
Enrico Beccastrini,
Mario Milco D’Elios,
Giacomo Emmi,
Elena Silvestri,
Danilo Squatrito,
Domenico Prisco,
Lorenzo Emmi
Publication year - 2013
Publication title -
international journal of immunopathology and pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.724
H-Index - 53
eISSN - 2058-7384
pISSN - 0394-6320
DOI - 10.1177/039463201302600302
Subject(s) - immunology , pathogenesis , epigenetics , innate immune system , medicine , immune system , lupus erythematosus , systemic lupus erythematosus , cytokine , biology , gene , disease , antibody , genetics , pathology
Systemic lupus erythematosus (SLE) is the prototype of autoimmune diseases with multiorgan involvement. SLE presents many genetic and epigenetic associations and the pathogenesis is characterized by a complex network of alterations affecting both adaptative and innate immunity. The disclosure of novel mechanisms of SLE pathogenesis suggested new therapeutic targets, based on interference with the cytokine pathways or on depletion of the immune cells.