Open AccessThe Role of C-Reactive Protein in Mood Disorders
Author(s) -
Domenico De Berardis,
Daniela Campanella,
Francesco Gambi,
Rita La Rovere,
Alessandro Carano,
Chiara Conti,
C Sivestrini,
Nicola Serroni,
D Piersanti,
Blasi Giuseppe,
Francesco Saverio Moschetta,
Carla Cotellessa,
Mario Fulcheri,
Rosa Maria Salerno,
Filippo Maria Ferro
Publication year - 2006
Publication title -
international journal of immunopathology and pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.724
H-Index - 53
eISSN - 2058-7384
pISSN - 0394-6320
DOI - 10.1177/039463200601900402
Subject(s) - mood disorders , c reactive protein , depression (economics) , mood , bipolar disorder , clinical psychology , medicine , depressive symptoms , psychology , psychiatry , inflammation , cognition , anxiety , economics , macroeconomics
Recently, a possible relationship between C-Reactive Protein (CRP), a marker of underlying low-grade inflammation, and mood disorders has been proposed by some researchers. The aim of this review is to elucidate the current facts and views about CRP in mood disorders such as Depressive and Bipolar Disorders. Several studies have examined the relationship between affective disorders and CRP, but the majority of the studies in literature have been limited by retrospective, case-controlled study design, and very few studies have examined the relationship between depression and CRP in large study samples. In conclusion, the role of CRP in mood disorders is, to date, intriguing but somewhat unclear. Further prospective studies are needed to introduce the CRP in clinical settings as a marker of affective states and suicidability.