Metadoxine in the Treatment of Acute and Chronic Alcoholism: A Review | Zendy

Giovanni Addolorato | Zendy; Carla Ancona | Zendy; Esmeralda Capristo | Zendy; Antonio Gasbarrini | Zendy

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Metadoxine in the Treatment of Acute and Chronic Alcoholism: A Review

Author(s) -

Giovanni Addolorato,

Carla Ancona,

Esmeralda Capristo,

Antonio Gasbarrini

Publication year - 2003

Publication title -

international journal of immunopathology and pharmacology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.724

H-Index - 53

eISSN - 2058-7384

pISSN - 0394-6320

DOI - 10.1177/039463200301600304

Subject(s) - medicine , alcohol , pharmacology , alcohol abuse , psychiatry , chemistry , biochemistry

Alcohol abuse and alcoholism are responsible for a wide variety of medical problems. The pharmacotherapeutic aspect of alcoholism includes the use of drugs, with different actions and objectives. Among them, metadoxine seems to be of interest. Metadoxine is able to accelerate the elimination of alcohol from the blood and tissues, to help restore the functional structure of the liver and to relieve neuro-psychological disorders associated with alcohol intoxication. Metadoxine also seems to be safe; in more than 15 years of post-marketing surveillance only minor aspecific and reversible events were monitored in patients exposed to the treatment. In this review the preclinical and clinical results obtained using metadoxine in acute and chronic alcohol intoxication are reported.

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