Open AccessCox-2 Selective Inhibitors and Bone
Author(s) -
Stuart B. Goodman,
Ting Ma,
Mark C. Genovese,
Robert L. Smith
Publication year - 2003
Publication title -
international journal of immunopathology and pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.724
H-Index - 53
eISSN - 2058-7384
pISSN - 0394-6320
DOI - 10.1177/039463200301600303
Subject(s) - medicine , adverse effect , pharmacology , bone healing , inflammation , bone remodeling , animal studies , bioinformatics , surgery , biology
Non-steroidal anti-inflammatory drugs (NSAIDs) are widely prescribed medications for relief of pain and inflammation. Recent animal studies using models of fracture healing and bone ingrowth suggest that NSAIDs (both non-selective NSAIDs and selective COX-2 inhibitors) adversely affect these bone-related processes. The dose and time-relationships of these medications and their resulting effects on bone have not yet been fully elucidated. Furthermore, whether COX-2 inhibitors and non-selective NSAIDs lead to clinically relevant adverse effects on bone healing in humans is unknown.