Open AccessDonor-Specific Human Leukocyte Antigen Antibody Formation After Allograft Glenoid Reconstruction Occurs But Does Not Impact Clinicoradiographic Outcomes
Author(s) -
Daniel R. Liwski,
Robert Liwski,
Ivan Wong
Publication year - 2021
Publication title -
the american journal of sports medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.021
H-Index - 221
eISSN - 1552-3365
pISSN - 0363-5465
DOI - 10.1177/0363546521996701
Subject(s) - medicine , resorption , human leukocyte antigen , sensitization , bone resorption , antibody , surgery , antigen , gastroenterology , immunology
Recurrent shoulder instability is a prevalent condition, with glenoid bone loss as a common cause. Arthroscopic repair using distal tibial allografts provides long-lasting treatment by restoring glenoid surface area and presumably avoids risks of sensitization against donor human leukocyte antigen (HLA). Two case studies have challenged this assumption, suggesting that small bone allografts are able to induce host adaptive immune responses to donor HLA. The incidence of small bone allograft HLA sensitization and its effects on resorption and patient outcomes are unclear.