The Effect of Hyoscine and Atropine on the Lower Oesophageal Sphincter | Zendy

John G. BrockUtne | Zendy; Joseph Rubin | Zendy; R. McAravey | Zendy; T. G. B. Dow | Zendy; Shaun Welman | Zendy; G. Dimopoulos | Zendy; M G Moshal | Zendy

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The Effect of Hyoscine and Atropine on the Lower Oesophageal Sphincter

Author(s) -

John G. BrockUtne,

Joseph Rubin,

R. McAravey,

T. G. B. Dow,

Shaun Welman,

G. Dimopoulos,

M G Moshal

Publication year - 1977

Publication title -

anaesthesia and intensive care

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.494

H-Index - 62

eISSN - 1448-0271

pISSN - 0310-057X

DOI - 10.1177/0310057x7700500306

Subject(s) - medicine , atropine , reflux , esophageal sphincter , sphincter , anesthesia , incidence (geometry) , gastroenterology , surgery , disease , physics , optics

The effects of intravenous hyoscine 0·4 mg and atropine 0·6 mg on lower oesophageal sphincter tone were studied in normal human subjects. Hyoscine and atropine both decreased the lower oesophageal sphincter (L.O.S) pressure by approximately 11 cm H 2 O (p <0·01). There was also an increased incidence of reflux as seen by an indwelling pH electrode in the lower oesophagus. These findings are relevant to the preoperative preparation of patients presenting for emergency obstetrical anaesthesia; since gastro-oesophagus reflux and pulmonary aspiration of acid gastric content continues to be a significant cause of morbidity and mortality.

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