Morphological and Immunohistochemical Characterization of Spontaneous Mammary Gland Tumors in the Guinea Pig (Cavia porcellus) | Zendy

Alejandro SuárezBonnet | Zendy; J. Martı́n de las Mulas | Zendy; M. Y. Millán | Zendy; P. Herráez | Zendy; F. Rodrı́guez | Zendy; A. Espinosa de los Monteros | Zendy

Open Access

Morphological and Immunohistochemical Characterization of Spontaneous Mammary Gland Tumors in the Guinea Pig (Cavia porcellus)

Author(s) -

Alejandro SuárezBonnet,

J. Martı́n de las Mulas,

M. Y. Millán,

P. Herráez,

F. Rodrı́guez,

A. Espinosa de los Monteros

Publication year - 2009

Publication title -

veterinary pathology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.794

H-Index - 89

eISSN - 1544-2217

pISSN - 0300-9858

DOI - 10.1177/0300985809358426

Subject(s) - myoepithelial cell , cytokeratin , cavia , immunohistochemistry , mammary gland , pathology , biology , guinea pig , mammary tumor , cancer , medicine , endocrinology , breast cancer , genetics

Ten spontaneous mammary gland tumors affecting guinea pigs (GP) were analyzed histologically and immunohistochemically. Histologically, 3 were benign (2 simple adenomas and 1 benign mixed tumor) and 7 were malignant (1 simple solid carcinoma and 6 simple tubulopapillary carcinomas). Immunohistochemical data revealed the glandular immunoprofile of all the tumors and suggested their ductal origin on the basis of cytokeratin 20 expression. Interestingly, cytokeratin 7 was detected in basal/myoepithelial cells. Further, all tumors were positive for type α estrogen and progesterone receptors, suggesting a role for steroid hormones in the development of these neoplasias in GP. This article describes the morphological and immunohistochemical features of the normal mammary gland and spontaneous mammary gland tumors in GP.

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